Aminophylline Suppository 500mg Bronchodilators
Each suppository contains Aminophykkine 500mg
PHARMACOLOGICAL ACTION :
Aminophylline is a soluble complex containing approximately 85%
theophylline and 15% ethylenediamine. Aminophylline directly
relaxes the smooth muscle of the bronchial airways and pulmonary
blood vessels, thus acting mainly as a bronchodilator, pulmonary
vasodilator and smooth muscle relaxant.
AMINOPHYLLIN is indicated for relief of acute bronchial asthma and
reversible bronchospasm associated with chronic bronchitis and
emphysema, and in status asthmaticus; congestive heart failure;
Cheyne-Stokes respiration; reduction of coughing, expectoration and
exertional dyspnoea in emphysema patients, and for cardiac
AMINOPHYLLIN SUPPOSICONES are intended for use in conditions
requiring less urgent and more prolonged administration.
AMINOPHYLLIN INJECTIONS are primarily for use in emergency
AMINOPHYLLIN should not be given to patients with active peptic
ulcers, since it may increase the volume and acidity of gastric
secretions. Patients with a history of hypersensitivity to
aminophylline or theophylline should not be treated with
AMINOPHYLLIN. Do not administer AMINOPHYLLIN with other xanthine
preparations. Safe use of AMINOPHYLLIN in pregnancy has not been
DOSAGE AND DIRECTIONS FOR USE:
Adults: One 500 mg supposicone once or twice daily.
Children: Use of the 500 mg supposicone is not recommended.
Supposicones must be removed from Rotoplast shells before use.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Some children may be unusually sensitive to AMINOPHYLLIN.
Administration of ephedrine or other sympathomimetic drugs to
patients already on treatment with AMINOPHYLLIN may result in toxic
Use with caution in patients with severe cardiac disease,
hypertension, hyperthyroidism, acute myocardial injury, cor
pulmonale, severe hypoxemia, hepatic impairment, or alcoholism, and
in the elderly (especially males) and in neonates. Particular
caution in dose administration must be exercised in patients with a
history of peptic ulcer since the condition may be exacerbated.
Caution should be used in giving aminophylline to patients in
congestive heart failure. Serum levels in such patients may persist
for long periods following discontinuation of the medicine.
Theophylline half-life is shorter in smokers than non-smokers;
therefore, smokers may require larger or more frequent doses.
Aminophylline may lower the seizure threshold.
Elevated serum levels of theophylline may occur in patients treated
concomitantly with aminophylline and cimetidine, troleandomycin,
erythromycin, allopurinol, or oral contraceptive steroids.
Co-medication with phenobarbitone, phenytoin, or rifampicin may
increase theophylline clearance and an increase of the
aminophylline dose may be required. The excretion of lithium
carbonate is increased in patients receiving aminophylline.
Consumption of coffee, tea, cola beverages, chocolate, or
paracetamol contributes to falsely high serum theophylline levels
when theophylline is measured spectrophotometrically without
previous isolation by chromatography.
The most consistent adverse reactions observed with therapeutic
amounts of aminophylline are:
|1.||Gastrointestinal: nausea, vomiting, anorexia, bitter aftertaste,
dyspepsia, heavy feeling in the stomach, and gastrointestinal
|2.||Central nervous system: dizziness, vertigo, light-headedness,
headache, nervousness, insomnia, and agitation.|
|3.||Cardiovascular: palpitation, tachycardia, flushing, extrasystoles
and cardiac rhythm disturbances.|
|4.||Respiratory: increase in respiratory rate.|
Proctitis may follow the repeated administration of aminophylline
suppositories. The benzocaine in the suppositories may cause local
Store in a cool dry place (below 25°C) away from light.
Keep out of reach of children.