Cephalexin For Oral Suspension Drugs 250MG / 5ML 60ML 1Bootle / Box
Cephalexin For Oral Suspension Drugs 250MG / 5ML 60ML
Each 5 ML Oral Suspension contains: Cephalexin 250MG
Cephalexin is an acid-stable cephalosporin and is well absorbed
from the gastro-intestinal tract. Peak plasma concentrations,
reached at about 1 hour after ingestion of the drug, are
approximately 9 and 18 ug/mL after oral doses of 250 and 500 mg,
Cephalexin inhibits bacterial cell-wall synthesis in a manner
similar to that of penicillin. In-vitro sensitivity does not
necessarily indicate in-vivo efficacy. Cephalexin is active in
vitro against both gram-positive and gram-negative micro-organisms.
Group A Strep. pyogenes, the viridans group, and non-hemolytic
streptococci, Strep. (D.) pneumoniae, penicillin-resistant and
penicillin-sensitive Staph. aureus, Staph. epidermis, Cl.
perfringens, List. monocytogenes, B. subtilis, C. diphtheriae, N.
gonorrhoeae, N. meningitides, and A. israelii are highly sensitive
to this agent, many being suppressed by concentrations of 0,004 to
Gram-negative bacteria are generally less susceptible, but the
majority strains of Salmonella, including S. typhi, most Shigella,
all Pr. mirabilis, and about 75% of E. coli, 60 % of para-colon
strains are inhibited by 1 to 6 ug/mL. Indole-producing strains of
Proteus Enterobacter (Aerobacter), Pseudomonas, and an occasional
strain of Klebsiella are highly resistant to cephalexin.
Enterococci and H. influenza are also insensitive to the drug.
The ingestion of food may delay absorption.
Infections caused by susceptible organisms.
Patients who are known or suspected to be allergic to other
cephalosporins should not be treated with cephalexin.
DOSAGE AND DIRECTIONS FOR USE:
The usual adult dose is 250-500 mg every 6 hours and for children
25 to 50 mg per kg body mass daily in divided doses.
When high doses are required the use of a parenteral cephalosporin
should be considered. In patients with impaired kidney function
smaller doses should be employed: with creatinine clearances of 5,
20 and 50 mL per minute, daily doses should not exceed 0,5, 1,5 and
3 g respectively and 8, 25 and 50 mg per kg respectively in
To make up to 100 mL, add 54 mL of water, invert bottle and shake
until all powder is dispersed.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Side-effects include nausea, vomiting, diarrhoea and abdominal
discomfort. Skin rashes occur in about 1% of patients treated with
cephalexin and rises in serum transaminases have been noted.
Eosinophilia and neutropenia have occurred in a few patients.
Supra-infection with resistant micro-organisms, particularly
Candida, may follow treatment.
Care is necessary in treating patients known to be hypersensitive
to penicillin or with known histories of allergy. Reduced dosage is
necessary in patients with impaired kidney function.
The urine of patients taking cephalexin may give a false positive
reaction for glucose with copper-reduction reagents. Positive
results to the Coomb's test have been reported with cephalexin.
Containers should be kept tightly closed, stored below 25°C and in
a dry place. Protect from light. Once dispensed, the syrup must be
used within 14 days if stored in a refrigerator. If stored at room
temperature, use within 7 days. Shake the bottle before use.
KEEP OUT OF REACH OF CHILDREN