AMPICILLIN 500 MG Capsules
Each capsule contains ampicillin trihydrate equivalent to 500 mg
Ampicillin is a bactericidal broad spectrum penicillin.
Infections due to susceptible organisms.
Ampicillin should not be given to patients known to be allergic to
penicillin nor, in the neo-natal period, to babies born of
Ampicillin should not be given to patients with infectious
mononucleosis since they are especially susceptible to
ampicillin-induced rashes, patients with lymphatic leukaemia and
patients with hyperuricaemia being treated with allopurinol, since
they may be at increased risk of developing ampicillin-induced skin
Ampicillin may cause reactions typical of penicillin allergy. In
patients with a history of penicillin or cephalosporin allergy
Ampicillin should be used with caution.
DOSAGE AND DIRECTIONS FOR USE:
Adults: 250 mg to 750 mg every 6 hours.
Children 0 - 6 years: 62,5 mg to 187,5 mg every 6 hours.
Children 7 - 10 years: 125 mg to 375 mg every 6 hours.
Children over 10 years: 250 mg to 750 mg every 6 hours.
In severe infections doses may be increased or high doses
administered parenterally.Ampicillin should be taken 30 minutes to 1 hour before meals. In patients with
renal impairment dosage may be reduced if required.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Overgrowth of non-susceptible organisms (Aerobacter aerogenes,
Pseudomonas, Candida, etc.) may occur and under these
circumstances, Ampicillin treatment should be discontinued and
specific or supportive therapy instituted. Diarrhoea, nausea,
vomiting, heartburn and pruritis ani may occur. When Ampicillin is
administered to a hypersensitive patient, allergic reactions may
occur. Urticaria and maculopapular skin rashes are common,
exfoliative dermatitis, eosinophilia, angioneurotic oedema,
erythema multiforme, fever and swollen joints may occur.
Allergic reactions which may be fatal such as anaphylaxis may
occur. These reactions may be common after parenteral use but may
also occur after oral administration. If serious anaphylactic
reaction occurs, Ampicillin should be discontinued and the patient
treated with adrenalin, corticosteriods and antihistamines. The
onset of the symptoms varies: it may occur within a few days of the
beginning of treatment or not until therapy with a penicillin
derivative is resumed on a subsequent occasion. In cases of
ampicillin treatment of mononucleosis a rash usually appears.
Severe pseudomembranous colitis may occur. Raised serum
aminotransferase concentrations have been reported.
Use with caution in patients with syphylis as the Jarish-Herxheimer
reaction may occur.
Store below 25°C. Protect from moisture.
KEEP OUT OF REACH OF CHILDREN.