INDOMETHACIN 25 MG Capsules
Each capsule contains 25 mg indomethacin.
Indomethacin has analgesic, anti-inflammatory and antipyretic
properties and inhibits the biosynthesis of prostaglandins:
This action may be the basis of its anti-inflammatory and
anti-pyretic properties (and certain of its other effects). It
inhibits motility of polymorphonuclear leucocytes and in
supratherapeutic concentrations uncouples oxidative phosphorylation
in cartilaginous and hepatic mitochondria.
Indomethacin is used to relieve the painful symptoms of ankylosing
spondylitits and osteoarthritis, and to relieve the pain and
swelling in gout, rheumatoid arthritis, and acute musculoskeletal
Indomethacin should not be used in pregnant women, children, or
patients with psychiatric disorders, epilepsy, or Parkinsonism. It
also contra-indicated in individuals with renal disease or
ulcerative lesions of the stomach
Contra-indicated in persons hypersensitive to indomethacin, other
non-steroidal anti-inflammatory agents, or aspirin, nursing mothers
and in patients with bleeding disorders, active peptic ulcer,
gastritis, regional enteritis and ulcerative colitis. ACUFLEX may
cause dizziness, therefore, patients should be cautioned about
engaging in activities requiring mental alertness and motor
co-ordination, such as driving a car and operating machinery.
Serious interactions have been reported after the use of high doses
of methotrexate with indomethacin. The combined use of indomethacin
and diflunisal has been associated with fatal gastro-intestinal
haemorrhage. Therefore indomethacin and diflunisal should not be
DOSAGE AND DIRECTIONS FOR USE:
IT IS RECOMMENDED THAT INDOMETHACIN CAPSULES BE TAKEN WITH FOOD,
MILK OR ANTACIDS.
In rheumatic disorders the usual initial dosage is 25 mg twice or
thrice daily, increased, if required, up to 150 mg in divided
dosis. In acute peri-articular disorders and in low back pain 50 mg
may be given twice or thrice daily for about 10 days. In acute gout
50 mg may be given three or four times a day. Total daily dose
should not generally exceed 200 mg.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
The most frequent central nervous system effect is severe frontal
headache. Dizziness, vertigo, lightheadedness, and mental confusion
are frequent. Severe psychosis, hallucinations, and suicide have
been reported. Corneal opacities, visual-field changes, and pallor
of the optic disk have also occurred. Anorexia, nausea and
vomiting, dyspepsia, and diarrhoea may occur. Peptic ulceration,
possibly with gastro-intestinal haemorrhage may also occur and is
not always preceded by dyspepsia; there may be oesophageal
Store in a dry place below 25°C.
Protect from light.
KEEP OUT OF REACH OF CHILDREN