CLOXACILLIN 250 MG Capsules
Each capsule contains cloxacillin sodium equivalent to 250 mg or
500 mg cloxacillin.
Cloxacillin is a semi-synthetic penicillin, resistant to
penicillinase, and is therefore active against
Cloxacillin is in general less effective against organisms
susceptible to benzylpenicillin, such as streptococci, pneumococci
and non-penicillinase-producing staphylococci, and is not useful
against gram-negative bacteria.
Cloxacillin is indicated for the treatment of infections due to
penicillinase-producing staphylococci that are resistant to
benzylpenicillin. It is used against gram-positive staphylococcus
|skin and soft tissue infections, e.g. abscesses, cellulitis.|
Cloxacillin should not be given to patients with a history of
penicillin allergy or administered to neonates 0born
of mothers hypersensitive to penicillin.
Patients allergic to cephalosporins may also be allergic to
Cloxacillin is incompatible with aminoglycosides, tetracyclines,
erythromycin and polymyxin B.
Use with caution in patients with a known history of allergy to
When administered to a patient with penicillin sensitivity
anaphylactic shock may occur. Adrenaline, corticosteroids and
antihistamines should be used to treat anaphylaxis.
Due to the variability in intestinal absorption, oral
administration is not a suitable substitute for the parenteral
treatment of serious infections.
DOSAGE AND DIRECTIONS FOR USE:
|Adults:||One 500 mg capsule six hourly, administered one hour before meals.|
|One 250 mg capsule six hourly, administered one hour before meals.|
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Sensitivity reactions may include skin rashes, angioedema,
bronchospasm, serum sickness and anaphylaxis, 0and sometimes death
within minutes. Treatment with adrenaline, corticosteroids,
aminophyllin or antihistamines may be necessary. A generalised
sensitivity reaction can develop within a few hours or weeks of
commencing treatment, including urticaria, fever, joint pains and
eosinophilia. Other allergic reactions include exfoliative
dermatitis and maculopapular rashes, interstitial nephritis and
vasculitis. Haemolytic anaemia, leucopenia, prolonged bleeding time
and defective platelet function can occur.
Store in a dry place below 25°C.