Ampicillin sodium Injection 1.0G
Each vial contains:Ampicillin sodium BP equivalent to Ampicillin
anhydrous 1 g
A semi-synthetic aminopenicillin with an in vitro bactericidal action against a broad spectrum of non penicillinase
producing gram-positive and gram-negative pathogens. Being acid
stable it is well absorbed when given orally.
The following organisms are resistant to ampicillin: Enterobacter,
Pseudomonas, Klebsiella, Serratia, Acinetobacter and
Ampicillin is indicated in the treatment of infections caused by
susceptible strains of the following microorganisms:
Infections of the genitourinary tract caused by E coli, P. mirabilis and enterococci.
Respiratory tract and ENT infections e.g. pharynigitis, tonsillitis, sinusitis, laryngitis, otitis
media, bronchitis, pneumonia caused by various bacteria including
non-penicillinase-producing H. influenzae, staphylococci, and
streptococci including Streptococcus pneumoniae.
Infections of the gastro-intestinal tract caused by Shigella, S. typhosa and other Salmonella, E. coli, P.
mirabilis, and enterococci.
Gonorrhoea –N. gonorrhoeae (non penicillinase producing)
Meningitis –N. meningitidis (after confirmation by sensitiviity testing)
Miscellaneous infections e.g. Septicaemia, endocarditis and biliary tract infections. Skin
and soft tissue infections, bacteremia and as an adjunct in the
treatment of sepsis caused by Gram-negative bacteria.
Ampicillinis contra-indicated in individuals with a history of a
previous hypersensitivity reaction to any of the pencillins.
Patients allergic to cephalosporins or cephamycins may be allergic
to penicillins also. Ampicillin is also contra-indicated in
It is contra-indicated in babies born of hypersensitive mothers in
the neonatal period.
When administered to a patient with penicillin sensitivity,
anaphylactic shock may occur. Adrenaline corticosteroids and
antihistamines should be used to treat anaphylaxis. Use with
caution in patients with known history of allergy.
DOSAGE AND DIRECTIONS FOR USE:
Dosage varies with the type and the severity of the infection,
renal function, and age.
Doses for children should not exceed doses recommended for adults.
Parenteral administration is reserved for severe infections that
cannot be treated by oral ampicillin.
Children: Up to 400 mg per kg body mass per day, given in divided
doses four hourly.
Adults: Up to 12 g daily, given in divided doses 4 hourly.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Skin rashes are most common side effects and are erythematous,
pruritic and maculopapular. The rash which usually does not develop
within the first week of therapy, may cover the entire body
including the sole, palms, and oral mucosa. Other hypersensitivity
reactions that have been reported are skin rash, urticaria,
erythema multiforme and an occasional case of exfoliative
dermatitis. Anaphylaxis is the most serious reaction expierenced.
Usage in pregnancy
Animal reproduction studies have failed to demonstrate a risk to
the foetus, and there are no adequate and well controlled studies
in pregnant women.
Precautions:Careful history of sensitivity to allergens, including
previous hypersensitivity reactions to penicillins and
cephalosporins should be taken before instituting therapy.
Ampicillin should be discontinued if any rash occurs.
Store below 25°C, protected from moisture. Use the prepared
KEEP OUT OF REACH OF CHILDREN.