Ampicillin Cloxacillin For Injection 250MG+250MG
Sterile powder for preparing the equivalent of 250 mg ampicillin
and 250 mg cloxacillin per vial.
AMPICLOX exhibits in vivo and in vitro bactericidal activity against Gram-positive and Gram-negative
Both ampicillin and cloxacillin are acid stable and well absorbed
orally, giving peak serum levels about two hours after dosing. As
there is a linear dose/response in peak serum level after oral
administration of both components, doubling the dose virtually
doubles the peak serum levels.
The use of this antibiotic may lead to the appearance of resistant
strains of organisms and sensitivity resting should, therefore, be
carried out wherever possible, to ensure the appropriateness of the
Infections caused by susceptible organisms where a mixed infection
is present and includes penicillin-resistant staphylococci.
Known allergy to penicillin or cephalosporins. Cases of cross
sensitivity have been reported.
Babies born of hypersensitive mothers in the neonatal period.
The oral dosage forms are not recommended for chronic, severe, or
deep-seated infections such as subacute bacterial endocarditis,
meningitis or syphilis. AMPICLOX should not be administered by
sub-conjunctival injection or used as an eye drop as it contains
When administered to a patient with penicillin allergy anaphylactic
shock may occur. Adrenaline, corticosteroids and antihistamines
should be used to treat anaphylaxis. Use with caution in patients
with a known history of allergy.
Because of the variability in intestinal absorption of cloxacillin
containing products, oral administration is not a suitable
substitute for the parenteral route in treatment of severe
DOSAGE AND DIRECTIONS FOR USE:
|Adults and children over 10||:||500 mg –1 g intravenously or intramuscularly every 4 – 6 hours or
as dictated by the severity of the infection.|
|Children 2 –10 years*||:||Half the adult dose.|
|Children up to 2 years*||:||Quarter the adult dose.|
|Neonates*||:||75 mg (i.e. 1 neonatal vial) every 8 hours.|
|500 mg vial||–||add 1,5 mL of Water for Injections B.P. and shake vigorously.|
|500 mg vial||–||dissolve in 10 mL of Water for Injections B.P. by first dissolving
the contents of the vial in approximately 3 mL of the Water for
Injections B.P. and then withdrawing the dissolved contents into a
10 mL syringe containing the remaining Water for Injections B.P.|
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
AMPICLOX may produce diarrhoea, nausea and heartburn. Allergic reactions
which may include exfoliative dermatitis, other skin rashes,
interstitial nephritis and vasculitis may occur. In this event,
withdrawal of AMPICLOX and administration of an antihistamine will suffice in most cases.
Should a serious anaphylactic reaction occur.
A generalised sensitivity reaction with urticaria, fever, joint
pains and eosinophilia can develop within a few hours to several
weeks after starting treatment.
Containers of AMPICLOX 500 should be kept tightly closed in a cool (below 25°C), dry place.
KEEP OUT OF REACH OF CHILDREN.