Artemether Lumefantrin for Suspension 180MG+1080MG / 60ML 1Bottle /
Artemether+Lumefantrin Oral Suspension Anti malarial 180MG+1080MG/60ML
The combination of artemether and lumefantrine is used to treat
certain kinds of malaria infections. Artemether and lumefantrine
should not be used to prevent malaria. Artemether and lumefantrine
is in a class of medications called antimalarials. It works by
killing the organisms that cause malaria.
Each 180/1080 package contains Artemether 180mg and Lumefantrine
Each 360/2160 package contains Artemether 360mg and Lumefantrine
Excipients include Sodium Citrate, Carmellose Sodium, Sucrose,
Sodium Benzoate, Colloidal anhydrous silica, Aspartame, flavour.
Both components of tablets have their own action site in the
malarial parasite. The presence of the endoperioxide bridge in
Artemether (generating singlet oxygen and free radicals: those are
very cytotoxic to the plasmodia) appears to be essential for
antimalarial activity. Morphological changes of the parasitic
membranes induced by Artemether have been described, being the
result of free-radical action.
Lumefantrine interferes more in the polymerization processes.
Other in vitro tests suggest that both cause a marked diminution of
nucleic acid synthesis. Inhibition of protein synthesis as the
basic mechanism of action is suggested in studies which showed
morphological changes in ribosomes as well as in the endoplasmic
reticulum. Although Artemether acts essentially as a blood
schizonticide, tablets did clear gametocytes in comparative
Tablet is indicated for the treatment of malaria in children,
caused by all forms of Plasmodium including severe malaria caused
by multiple drug resistant strains of P. Falciparum.
Sensitivity to cimetidine or related agents.
Should not be administered to pregnant or lactating patients.
DOSAGE AND DIRECTIONS FOR USE:
Shake the bottle to loosen powder inside. Add water to the mark
point and shake well. Adjust the volume up to the mark if
necessary. The suspension must be used within one week after
preparation. Shake well before use.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
With Artemether virtually no side effects have been seen.
Laboratory abnormalities such as a slight rise in transaminases and
a decrease in reticulocyte count are rare and transient. A lowering
of sinus frequency without causing ECG changes has been noticed. At
high doses transient abdominal pain, tinnitus and diarrhea have
been described but a causal relationship is unclear.
Some antimalarials as halofantrine and quinine can influence the
ECG pattern. Attention should be made to patients previously
treated with those antimalarials. A reasonable period should be
taken in account before to start a. treatment with lumefantrine
combinations. For those patients physicians will be prescribed
Artemismin derivatives in mono therapy in cause of severe paludism.
Sometimes it could be possible that the following common side
effect occur; rash, check this with you doctor. Other common side
effects may occur as trouble of sleeping, nausea, vomiting,
diarrhea, coughing. They need medical attention when persisting.
Store below 25°C in a closed bottle. Once the suspension has been
made up, it is stable for a minimum of one week. Longer
conservation is not recommended. Protect from light.