Chloramphenicol eye ointment 1% 4g Antibiotics Aluminium tube 1
TUBE / BOX
Chloramphenicol eye ointment 1% 4g
Each gram contains:Chloramphenicol 10 mg
CHLORNICOL EYE OINTMENT has an antibiotic spectrum that covers
Gram-positive and Gram-negative bacteria. It is primarily
bacteriostatic and acts by inhibition of protein synthesis.
Eye infections caused by susceptible organisms.
Patients with known sensitivity or toxic reaction to
Minor infections or as a prophylactic agent to prevent bacterial
During active immunisation and during concomitant administration
with other medicines liable to depress bone marrow function.
Pregnancy and lactation.
Because of the risk of the Grey syndrome, CHLORNICOL EYE OINTMENT
should never be used in newborn infants unless it may be
life-saving and there is no alternative treatment.
Repeated courses and prolonged treatment should be avoided.
DOSAGE AND DIRECTIONS FOR USE:
Instill into the affected eyes two or three times a day.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Although this preparation is an eye ointment, sufficient
chloramphenicol may be absorbed to produce adverse effects.
Chloramphenicol may cause serious and sometimes fatal adverse
effects and it should be discontinued on the appearance of toxic
The most serious adverse effect is depression of the bone marrow,
and it can take two different forms.
The first form is dose-related, reversible depression occurring
usually when the plasma-chloramphenicol concentrations exceed 25
micrograms per mL and is characterised by morphological changes in
the bone marrow, decreased iron utilisation, reticulocytopenia,
anaemia, leucopenia and thrombocytopenia.
The second form is a severe, irreversible aplastic anaemia with a
high rate of mortality. Bone marrow aplasia and hypoplasia may
appear weeks or months after therapy.
Routine blood examinations are advisable, but will not warn of
Haemolytic anaemia has occurred in some persons with a genetic
deficiency of glucose-6-phosphate dehydrogenase activity.
A toxic manifestation - the Grey syndrome - which is characterised
by abdominal distension, vomiting, ashen colour, hypothermia,
progressive pallid cyanosis, irregular respiration and circulatory
collapse followed by death in a few hours or days, has occurred in
premature and newborn infants treated with large doses of
chloramphenicol. In most cases the oral dose of chloramphenicol has
been more than 25 micrograms per kg body mass. A similar syndrome
has been reported in adults and older children given very high
Peripheral as well as optic neuritis has been reported in patients
treated with chloramphenicol, usually over prolonged periods.
although ocular symptoms are often reversible if treatment is
withdrawn early, optic atrophy with blindness has occurred.
Sensitivity reactions may occur. Jarisch-Herxheimer-like reactions
may also occur.
Excessive blood concentrations may also occur following
administration of usual doses to patients with renal failure,
impaired liver function, and in premature and full-term neonates
who have immature metabolic processes.
Chloramphenicol is inactivated in the liver and may therefore
interact with medicines which are metabolised by hepatic microsomal
Chloramphenicol enhances the effects of coumarin anticoagulants
such as dicoumarol and warfarin sodium, some hypoglycaemic agents
such as chlorpropamide and tolbutamide and antiepileptics such as
The half-life or plasma-concentrations of chloramphenicol may be
affected by paracetamol, phenobarbitone, phenytoin, or rifampicin.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Refer to "Side-effects and special precautions".
Treatment of overdosage is symptomatic and supportive.
Store below 15℃, protect from light.
KEEP OUT OF REACH OF CHILDREN.